Eight people were taken to hospital after a major crash on the Calder Highway at Carwarp at 2.40pm Sunday.
Those taken to hospital suffered a variety of injuries including leg injries, broken collarbone and broken ribs.
One of those injured in a bizarre accident has subsequently been flown by air ambulance to Melbourne and is in critical condition.
Police investigations into the accident are continuing as it involved a motor bike and three vehicles.
Police indicated that a Holden Commodore Station Wagon towing a trailer loaded with grapes may have attempted to pass a motor bike on the highway about 10 kilometres south of Red Cliffs.
But as the 66 year old Melbourne driver pulled out to overtake he was confronted with oncoming traffic and attempted to return to his position.
It’s believed the trailer began to sway and the Station Wagon struck the drivers side of a Kia Van heading towards Red Cliffs.
The impact turned the Kia on to its side (pictured) trapping the 55 year old Mildura driver, who received severe leg injuries and was taken to Mildura Base Hospital
The Commodore apparently was forced back to its correct side of the highway but was written off as a result of the impact.
The 66 year old driver suffered leg injuries, along with a 64 year old Melbourne passenger, who also received leg injuries.
Two women sitting in the back seat, one aged 61 and the other aged 62, were both injured and taken to Mildura Base Hospital for treatment.
A third vehicle became involved in the crash when it tried to avoid the two vehicles which had collided.
A Twin Cab Utility was travelling towards Red Cliffs behind the Kia Van and the 52 year old driver from Cardross took evasive action but lost control and the vehicle rolled over.
The driver, along with a 52 year old Mildura male passsenger and a 65 year old male, also from Mildura,
All three occupants of the Utility were taken to Hospital for treatment.
The Can-Am three wheeled bike which was being ridden by a male with female pillion passenger, was heading towards Bairnsdale after attending the annual Ulysses AGM at Mildura.
Neither was hurt as the rider had been able to control his bike as it went off the bitumen and on to gravel shoulder service.
The rider had edged to the left to get around the accident scene and then stopped about 50 metres down the highway.
The accident scene was attended by several ambulances, eight policemen, three Fire Brigade Units and the SES which used its equipment to free the driver from the crashed Kia van.
The Calder Highway was closed for about three hours with traffic initially being diverted to the other side of the Mildura to Melbourne railway line and later a truck temporary bypass was organized through Karadoc.